Synergism between ipratropium and theophylline in asthma.

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Synergism between ipratropium and theophylline in asthma.

Ipratropium bromide is a bronchodilator whose effect has been compared with beta agonists but not with theophylline. Twelve asthmatics were given four two-week courses of the different combinations of ipratropium (40 micrograms in two puffs), theophylline capsules, and their corresponding placebos in a random, double-blind fashion. There was a significant increase in FEV1 and MMFR 60 minutes af...

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Salbutamol and ipratropium in acute asthma.

Thirty seven children with acute asthma were given nebulised ipratropium or placebo 30 minutes after their first dose of salbutamol and eight hourly thereafter. There were no significant differences between the two groups in clinical scores, peak expiratory flow rates, length of stay in hospital, or the need for oral steroids.

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Nebulised ipratropium and salbutamol in asthma.

Treatment with nebulised salbutamol or a mixture of salbutamol and ipratropium was given to 138 children. Length of hospital stay and number of nebulised doses required did not differ. In severe asthma response was greater with salbutamol alone. In mild asthma response was greater with combined treatment.

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Ipratropium bromide in children with asthma.

Eighteen children between 6 and 14 years of age with perennial asthma were studied over two four-week treatment periods. Ipratropium bromide, given in addition to their current treatment, was compared with placebo using a double-blind crossover technique. The period of treatment with ipratropium was associated with a significant reduction in symptoms during both day and night and significantly ...

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Combined ipratropium and beta2--adrenergic receptor agonist in acute asthma.

Editors' Note: This munth we continue the new feature STEPped Care: An Evidence-BtlSedApproach to Drug Therapy. These articles are designed to provide concise answers to the drug therapy questions that family physicians encounter in their daily practice. The format of the feature will follow the mnemunic STEP: safety (an analysis of adverse effects that patients and providers care about), toler...

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ژورنال

عنوان ژورنال: Thorax

سال: 1981

ISSN: 0040-6376

DOI: 10.1136/thx.36.5.387